Responsible Researcher: Dr. Houria Boulaiz Tassi (@email)
Functionalized Nanoparticles for Targeted Drug and Therapeutic Agent Delivery.
Identification and Development of New Molecules for Molecular Targets in Cancer.
Targeted Gene Therapy for Oncology and Rare Diseases.
Responsible Researcher: Dr. Mariana Fernández Cabrera (@email)
- Biomonitoring of human exposure (Epidemiology and prevention of diseases resulting from environmental chemical exposures).
- Endocrine Disruption
- Intervention strategies for health promotion and disease prevention
- Management of databases in health (Big data)
Responsable: Dr. José Luis Quiles Morales. (@email)
At the Food4HealthLab of the University of Granada, we study the role of nutrition in health and disease, with a particular focus on healthy aging and age-related diseases (periodontitis, neurodegenerative diseases, etc.). Our research explores the effects of nutrients and bioactive compounds from foods and agro-food by-products, combining preclinical and clinical approaches. We focus on mitochondrial biology, oxidative stress, and redox regulation as key processes in maintaining health. Our lab has a strong facility on the experimental model Caehorhabditis elegans.
Responsible Researcher: Dr. Margarita Rivera Sánchez (@email)
Shared genetic and environmental factors between physical and mental disorders.
Physical health in individuals with mental disorders.
Use of bioinformatics tools and large-scale statistical analyses to investigate the relationship between physical and mental disorders.
Responsible Researcher: Dr. Cristina Sánchez (@email), Pilar Aranda (@email) and Juan Llopis (@email)
Effects and applications of nanoparticles and metal coordination compounds in biological systems.
Study of mineral metabolism and the role of trace and ultra-trace elements in physiological and pathological situations.
Studies of exposure to toxic environmental conaminants.
Analysis of mineral composition and trace and ultra-trace elements in foods and simples of biological and biomedical interest.
Assessment of the nutritional status of populations in physiological and pathological situations.
Bioactivity analysis and evaluation of the nutritional value of naturally occurring matrices.
Responsible Researcher: Dr. Germaine Escames (@email); Dr. Luis Carlos López García (@email); Dra Iryna Rusanova (@email); Laura Jiménez Sánchez (@email); Carmen Venegas (@email); Pablo Ranea (@email); https://grupoinvestigacion-cts101.es
· Mechanisms of action of melatonin. Nucleus-mitochondria connection
· Regulation of mitochondrial bioenergetics by melatonin
· Chronodisruption, oxidative and inflammatory stress, and mitochondrial damage in aging
· Study of clock genes in cellular and mitochondrial damage in experimental models of Parkinson's disease and sepsis
· Melatonin and its metabolites as new pharmacological tools in cancer
· Chronobiology of cancer
· Mechanisms to prevent chemo- and radioresistance
· Melatonin and mucositis
· Mitochondrial physiology. Pathophysiological mechanisms and therapeutic strategies in mitochondrial diseases
· Cellular and animal models of mitochondrial diseases
· Primary coenzyme Q10 deficiency
· Mitochondrial Complex I deficiency
· Hydrogen sulfide metabolism
· Pharmacological, cellular, and genetic therapies
· Mitochondria and exo-miRNAs: therapeutic targets for treating endothelial dysfunction in diabetes
· Mitochondrial encephalopathies associated with sulfur metabolism disorders
· Senescence and inflammation in neurodegenerative diseases
· Peroxisomes and metabolic homeostasis
Responsible Researcher: Dr. Mª Inmaculada López Aliaga (@email), Mª José Muñoz Alférez (@email), Teresa Nestares Pleguezuelo (@email), Javier Díaz Castro (@email) and Jorge Moreno Fernández (@email)
Bioavailability of macro and micronutrients in health and disease: dietary modifications.
Nutritional iron deficiency anemia: modifications in cellular signaling pathways and patterns of gene and protein expression mediated by nutrients.
Goat milk as a nutraceutical, bioactive components and health effects.
Responsible Researcher: Dr. Teresa Nestares Pleguezuelo (@email)
Celiac desease and gluten free diet
Responsible Researcher: Dr. Inmaculada Llamas Company (illamas@ugr.es)
Microbial biodiversity
Study of exopolysaccharides produced by halophilic bacteria
Study of intercellular communication systems and their interference
Selection of bacteria of interest in agriculture
Selection of enzymes of industrial and agricultural interest
Responsible Researcher: Dr. Margarita Aguilera Gómez (@email) and Mercedes Monteoliva Sánchez (@email)
Intestinal Microbiota and Probiotics: Biotechnological resources of interest in nutrition and health
Microbial Phylogeny and Taxonomy
Genetic Biomarkers
Responsible Researcher: Dr. Laura Vera Ramírez (@email). https://www.ugr.es/~tumor.dormancy.lab/
Study of the molecular mechanisms regulating the establishment and maintenance of dormancy in disseminated tumor cells.
Analysis of the molecular mechanisms that regulate the dormant-to -proliferative switch of disseminated tumor cells.
Development of new tumor dormancy models
Responsible Researcher: Dr. Enrique J Cobos del Moral (@email), Francisco R Nieto López (@email), Rafael González Cano (@email) and Miguel Ángel Tejada Giráldez (@email)
New pharmacological targets for pain treatment
Sigma receptors
Neuroimmune interactions in pain states
Associations of analgesic drugs to improve their therapeutic range
Artificial intelligence tools for the evaluation of rodent behavior
Responsible Researcher: Dr. Rafael Jiménez Medina (@email) and Francisco Barrionuevo Jiménez (@email)
Developmental Genetics and mammalian sex determination
Genetic basis of seasonal testis regression.
Genetic basis of non-obstructive azoospermia.
Responsible Researcher: Dr. María Dolores Mesa (@email) and Emilio Martínez de Victoria (@email)
Development of functional foods derived from olives and virgin olive oil.
In vitro and in vivo assays and nutritional clinical trials.
Responsible Researcher: Dr. Ángel Gil (@email), Carmen Piernas (@email) and M. Dolores Mesa (@email)
Dietary antioxidants
Clinical studies on nutritional components and dietary interventions in healthcare settings
Maternal and child health
Responsible Researcher: Dr. Julio José Ochoa Herrera (@email), Javier Díaz Castro (@email), Jorge Moreno Fernández (@email), Juan Manuel Toledano Dueñas (@email), María Puche Juárez (@email)
Influence of advanced maternal age on gestation and postnatal health.
COVID-19 and pregnancy
DHA supplementation in pregnancy and lactation.
Oropharyngeal colostrum intake.
Exercise, gestation and newborn development.
Early metabolic programming, advanced maternal age, mitochondrial rheostasis and microbiota. Implications on maternal-fetal health.
Influence of hormonal administration in transgender population. Physical and mental health implications.
