Clon de Líneas de investigación

Líneas de investigación

• Functionalized Nanoparticles for Targeted Drug and Therapeutic Agent Delivery.
• Identification and Development of New Molecules for Molecular Targets in Cancer.
• Targeted Gene Therapy for Oncology and Rare Diseases.

• - Biomonitoring of human exposure (Epidemiology and prevention of diseases resulting from environmental chemical exposures).
• - Endocrine Disruption
• - Intervention strategies for health promotion and disease prevention
• - Management of databases in health (Big data)

• At the Food4HealthLab of the University of Granada, we study the role of nutrition in health and disease, with a particular focus on healthy aging and age-related diseases (periodontitis, neurodegenerative diseases, etc.). Our research explores the effects of nutrients and bioactive compounds from foods and agro-food by-products, combining preclinical and clinical approaches. We focus on mitochondrial biology, oxidative stress, and redox regulation as key processes in maintaining health. Our lab has a strong facility on the experimental model Caehorhabditis elegans.

• Shared genetic and environmental factors between physical and mental disorders.
• Physical health in individuals with mental disorders.
• Use of bioinformatics tools and large-scale statistical analyses to investigate the relationship between physical and mental disorders.

• Effects and applications of nanoparticles and metal coordination compounds in biological systems.
• Study of mineral metabolism and the role of trace and ultra-trace elements in physiological and pathological situations.
• Studies of exposure to toxic environmental conaminants.
• Analysis of mineral composition and trace and ultra-trace elements in foods and simples of biological and biomedical interest.
• Assessment of the nutritional status of populations in physiological and pathological situations.
• Bioactivity analysis and evaluation of the nutritional value of naturally occurring matrices.

• ·  Mechanisms of action of melatonin. Nucleus-mitochondria connection
• ·  Regulation of mitochondrial bioenergetics by melatonin
• ·  Chronodisruption, oxidative and inflammatory stress, and mitochondrial damage in aging
• ·  Study of clock genes in cellular and mitochondrial damage in experimental models of Parkinson's disease and sepsis
• ·  Melatonin and its metabolites as new pharmacological tools in cancer
• ·  Chronobiology of cancer
• ·  Mechanisms to prevent chemo- and radioresistance
• ·  Melatonin and mucositis
• ·  Mitochondrial physiology. Pathophysiological mechanisms and therapeutic strategies in mitochondrial diseases
• ·  Cellular and animal models of mitochondrial diseases
• ·  Primary coenzyme Q10 deficiency
• ·  Mitochondrial Complex I deficiency
• ·  Hydrogen sulfide metabolism
• ·  Pharmacological, cellular, and genetic therapies
• ·  Mitochondria and exo-miRNAs: therapeutic targets for treating endothelial dysfunction in diabetes
• ·  Mitochondrial encephalopathies associated with sulfur metabolism disorders
• ·  Senescence and inflammation in neurodegenerative diseases
• ·  Peroxisomes and metabolic homeostasis

• Bioavailability of macro and micronutrients in health and disease: dietary modifications.
• Nutritional iron deficiency anemia: modifications in cellular signaling pathways and patterns of gene and protein expression mediated by nutrients.
• Goat milk as a nutraceutical, bioactive components and health effects.

• Celiac desease and gluten free diet

• Microbial biodiversity
• Study of exopolysaccharides produced by halophilic bacteria
• Study of intercellular communication systems and their interference
• Selection of bacteria of interest in agriculture
• Selection of enzymes of industrial and agricultural interest

• Intestinal Microbiota and Probiotics: Biotechnological resources of interest in nutrition and health
• Microbial Phylogeny and Taxonomy
• Genetic Biomarkers

• Study of the molecular mechanisms regulating the establishment and maintenance of dormancy in disseminated tumor cells.
• Analysis of the molecular mechanisms that regulate the dormant-to -proliferative switch of disseminated tumor cells.
• Development of new tumor dormancy models

• New pharmacological targets for pain treatment
• Sigma receptors
• Neuroimmune interactions in pain states
• Associations of analgesic drugs to improve their therapeutic range
• Artificial intelligence tools for the evaluation of rodent behavior

•     Developmental Genetics and mammalian sex determination
•     Genetic basis of seasonal testis regression.
•     Genetic basis of non-obstructive azoospermia.

• Development of functional foods derived from olives and virgin olive oil.
• In vitro and in vivo assays and nutritional clinical trials.

• Dietary antioxidants
• Clinical studies on nutritional components and dietary interventions in healthcare settings
• Maternal and child health

• Influence of advanced maternal age on gestation and postnatal health.
• COVID-19 and pregnancy
• DHA supplementation in pregnancy and lactation.
• Oropharyngeal colostrum intake.
• Exercise, gestation and newborn development.
• Early metabolic programming, advanced maternal age, mitochondrial rheostasis and microbiota. Implications on maternal-fetal health.
• Influence of hormonal administration in transgender population. Physical and mental health implications.